Real Madrid will have the weekend off after their request to postpone the La Liga clash with Athletic Bilbao was granted.
The decision by Conmebol to extend their international round by an additional day meant a host of South American players would not be back in time for the weekend.
However, David Alaba has returned injured to Real Madrid after being away on international duty with Austria.
With Eder Militao also in the same situation after suffering a setback against Brazil, it leaves Carlo Ancelotti’s defensive plans in chaos ahead of his side’s Champions League trip to Shakhtar Donetsk on Tuesday.
With Dani Carvajal also still sidelined, it leaves Los Blancos without three of their customary starters at the back.
If Alaba and Militao do miss out, then Ancelotti could line up with Nacho Fernandez and Jesus Vallejo at centre-back, with Lucas Vazquez at right-back and either Marcelo or Ferland Mendy at left-back.
But both are without recent game time, with Marcelo featuring for just two minutes this term, while Mendy has been out of action since March.