After winning this year’s Australian Open, French Open and Wimbledon, a fourth victory for Djokovic at Flushing Meadows will enable him to move past Roger Federer and Rafael Nadal on majors won.
The World No. 1 will stand alone at the top of the major slams won with 21 titles with victory in New York.
The Serbian is also bidding to become just the second male player in the Open Era (since April 1968) to complete a Grand Slam.
Only five players have previously won all four majors in the same year, with Australian great Rod Laver the only man to have achieved the feat in the Open era.
The Serbian starts on Tuesday against Danish teenager Holger Rune, who came through qualifying to reach his first Grand Slam main draw.
“There’s no doubt that Djokovic is the clear favourite to win the tournament, his form in the majors has been incredible – it speaks for itself,” former British number one Tim Henman said.
“To play so well on hard courts, clay courts, grass courts, I think it really emphasises what a complete player he is.
“So when I reflect on the chances of him completing all four, I think it’s Djokovic against the field.
